c-Myb mRNA degrader REM-422

{
  "id": "MLC-T-ONC-012683",
  "term": "c-Myb mRNA degrader REM-422",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small molecule mRNA degrader of the proto-oncogene c-Myb, with potential antineoplastic activity. Upon oral administration, c-Myb mRNA degrader REM-422 promotes the inclusion of poison exon into the c-Myb pre-mRNA transcript, resulting in the degradation of c-Myb mRNA and the reduction of both c-Myb mRNA and c-Myb protein levels. This may decrease proliferation in tumor cells with c-Myb dysregulation or overexpression. c-Myb, an oncogenic transcription factor that plays a key role in the regulation of hematopoietic cell differentiation and proliferation, is dysregulated or overexpressed in a variety of tumor cell types.",
  "synonyms": [
    "c-Myb mRNA inhibitor REM-422",
    "Myb mRNA degrader REM-422",
    "Myb mRNA inhibitor REM-422"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/c-myb-mrna-degrader-rem-422/"
}