Selective estrogen receptor degrader AND019

{
  "id": "MLC-T-ONC-016668",
  "term": "Selective estrogen receptor degrader AND019",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD AND019 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.",
  "synonyms": [
    "SERD AND019"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/selective-estrogen-receptor-degrader-and019/"
}