Taragarestrant

{
  "id": "MLC-T-ONC-016983",
  "term": "Taragarestrant",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, nonsteroidal selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, taragarestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.",
  "synonyms": [
    "selective estrogen receptor downregulator D-0502",
    "SERD D-0502"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/taragarestrant/"
}