SERD ZB716

{
  "id": "MLC-T-ONC-016687",
  "term": "SERD ZB716",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable selective estrogen receptor degrader/downregulator (SERD) and a structural analog of fulvestrant, with potential antineoplastic activity. Upon oral administration, SERD ZB-716 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.",
  "synonyms": [
    "selective estrogen receptor degrader ZB716",
    "ERalpha-coregulator degrader ZB716",
    "selective estrogen receptor alpha degrader ZB716",
    "borestrant"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/serd-zb716/"
}