giredestrant

{
  "id": "MLC-T-ONC-013947",
  "term": "giredestrant",
  "field": "Oncology and biomedicine",
  "definition": "An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, giredestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.",
  "synonyms": [
    "selective estrogen receptor degrader GDC-9545",
    "selective estrogen receptor downregulator GDC-9545",
    "SERD GDC-9545"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/giredestrant/"
}