CXCR4 inhibitor GPC-100

{
  "id": "MLC-T-ONC-012850",
  "term": "CXCR4 inhibitor GPC-100",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential hematopoietic stem cell (HSC)-mobilizing activity. Upon administration, CXCR4 inhibitor GPC-100 targets and binds to CXCR4, thereby preventing the binding of stromal-cell derived factor-1 (SDF-1; C-X-C motif chemokine ligand 12; CXCL12) to CXCR4. This results in HSC release from the bone marrow and HSC movement into the peripheral circulation. The CXCL12/CXCR4 signaling pathway plays an important role in the migration and retention of HSC in the bone marrow.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cxcr4-inhibitor-gpc-100/"
}