cyproterone acetate

{
  "id": "MLC-T-ONC-002223",
  "term": "cyproterone acetate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery.",
    "The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels."
  ],
  "abbreviation": "CyPat",
  "synonyms": [
    "cyproteronazetat",
    "Diane"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cyproterone-acetate/"
}