Dapsone

{
  "id": "MLC-T-ONC-002278",
  "term": "Dapsone",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat acne. It is also used to treat other types of skin diseases and certain bacterial infections, such as leprosy. It blocks bacteria from making a substance that they need to grow. Dapsone is a type of antibacterial agent and a type of anti-inflammatory agent.",
    "A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration."
  ],
  "abbreviation": "DADPS",
  "synonyms": [
    "croysulfone",
    "diphenasone",
    "dumitone",
    "novophone",
    "sulfona-mae",
    "sulphadione"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dapsone/"
}