darovasertib

{
  "id": "MLC-T-ONC-012928",
  "term": "darovasertib",
  "field": "Oncology and biomedicine",
  "definition": "An orally available protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Upon oral administration, darovasertib inds to and inhibits PKC, which prevents the activation of PKC-mediated signaling pathways. This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells. PKC, a serine/threonine protein kinase overexpressed in certain types of cancer cells, is involved in tumor cell differentiation, proliferation, invasion and survival.",
  "synonyms": [
    "protein kinase C inhibitor LXS196",
    "PKC inhibitor IDE196",
    "protein kinase C inhibitor IDE196"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/darovasertib/"
}