Safingol

{
  "id": "MLC-T-ONC-007534",
  "term": "Safingol",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors. Also called L-threo-dihydrosphingosine.",
    "A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo."
  ],
  "synonyms": [
    "L-threo-dihydrosphingosine",
    "sphinganine"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/safingol/"
}