PKC-beta inhibitor MS-553

{
  "id": "MLC-T-ONC-016098",
  "term": "PKC-beta inhibitor MS-553",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of the beta-isoform of protein kinase C (PKC), with potential immunosuppressive and antineoplastic activities. Upon oral administration, PKC-beta inhibitor MS-553 selectively binds to and inhibits PKC-beta, which prevents the activation of PKC-beta-mediated signaling pathways. This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells. PKC-beta, a serine/threonine protein kinase overexpressed in certain types of cancer cells, is involved in tumor cell differentiation, proliferation, invasion and survival.",
  "synonyms": [
    "PKC-b inhibitor MS-553"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pkc-beta-inhibitor-ms-553/"
}