dual variable domain immunoglobulin ABT-165

{
  "id": "MLC-T-ONC-013177",
  "term": "dual variable domain immunoglobulin ABT-165",
  "field": "Oncology and biomedicine",
  "definition": "A dual-specific, tetravalent immunoglobulin (Ig)G-like molecule targeting two as of yet not publicly known targets, with potential antineoplastic activity. The target-binding variable domains of two monoclonal antibodies, which are not publicly known, are combined, via linkers, to create the tetravalent, dual-targeting single agent ABT-165. Upon administration of dual variable domain immunoglobulin (DVD-Ig) ABT-165, the target-binding variable domains specifically recognize and simultaneously bind to their two antigens expressed on tumor cells. This may both prevent antigen-mediated signaling and lead to an inhibition of cellular proliferation in susceptible tumor cells. The antigen targets are overexpressed on certain tumor cell types. The DVD-Ig may have enhanced physicochemical and pharmacokinetic properties as compared to their antibody counterparts.",
  "synonyms": [
    "DVD-Ig ABT-165"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dual-variable-domain-immunoglobulin-abt-165/"
}