floxuridine

{
  "id": "MLC-T-ONC-003243",
  "term": "floxuridine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used in the treatment of cancer. It is a type of antimetabolite.",
    "A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis."
  ],
  "abbreviation": "5-FUDR",
  "synonyms": [
    "FdUrD",
    "floxuridin",
    "fluorodeoxyuridine",
    "fluoruridine deoxyribose",
    "fluorouridine deoxyribose"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/floxuridine/"
}