flucytosine

{
  "id": "MLC-T-ONC-003247",
  "term": "flucytosine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug that treats infections caused by fungi.",
    "A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis."
  ],
  "abbreviation": "5-FC",
  "synonyms": [
    "5-fluorocytosine"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/flucytosine/"
}