FLT3 agonist-Fc fusion protein GS-3583

{
  "id": "MLC-T-ONC-013625",
  "term": "FLT3 agonist-Fc fusion protein GS-3583",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein composed of fms-related tyrosine kinase 3 ligand (FLT3L) and agonist fused to an immunoglobulin (Ig) fragment crystallizable region (Fc region), with potential immunostimulating activity. Upon administration of the FLT3 agonist-Fc fusion protein GS-3583, the FLT3 agonist moiety specifically targets, binds to, and activates FLT3 and, synergistically with other growth factors, stimulates the proliferation and mobilization of bone marrow precursor cells, including CD34+ cells, and dendritic cells (DCs). FLT3 agonist-Fc fusion protein GS-3583 has a longer serum half-life compared with soluble FLT3L.",
  "synonyms": [
    "FLT3 agonist Fc fusion protein GS-3583",
    "Flt3R agonist GS-3583"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/flt3-agonist-fc-fusion-protein-gs-3583/"
}