fluorine F 18-4-L-fluoroglutamine (2S,4R)

{
  "id": "MLC-T-ONC-013702",
  "term": "fluorine F 18-4-L-fluoroglutamine (2S,4R)",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate and glutamine analog consisting of the fluorine F 18 labeled 2S, 4R stereoisomer of 4-fluoroglutamine with potential use as a metabolic tracer for tumor imaging. Upon intravenous administration, fluorine F 18-4-L-fluoroglutamine (2S,4R) is preferentially taken up by cancer cells, possibly driven by c-Myc upregulation. Upon positron emission tomography (PET), cancer cells can be imaged. Tumor cells use the amino acid glutamine for nutritional purposes necessary for energy production and growth; as tumor cells proliferate more rapidly than normal healthy cells, glutamine uptake is higher in certain cancer cells.",
  "abbreviation": "18F fluoroglutamine",
  "synonyms": [
    "fluorine F 18 4-L-fluoroglutamine (2S,4R)",
    "[18F] 4-L-fluoroglutamine (2S,4R)",
    "F-glutamine",
    "(2S,4R)4-FGln"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-4-l-fluoroglutamine-2s-4r/"
}