fluorine F 18-ara-G

{
  "id": "MLC-T-ONC-013713",
  "term": "fluorine F 18-ara-G",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the guanosine analog arabinosyl guanine (Ara-G), a high-affinity substrate for both cytoplasmic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (dGK), labeled with fluorine F 18, that can potentially be used as a tracer for imaging of activated T lymphocytes during positron emission tomography (PET). Upon administration, fluorine F 18-ara-G is taken up by and accumulates in activated T lymphocytes with high levels of DCK and dGK. After phosphorylation by DCK and dGK, the 18F moiety can be visualized by PET imaging. Fluorine F 18 ara-G can potentially be used as an imaging agent to detect anti-tumor immune responses and to predict the therapeutic efficacy of immunotherapies. DCK and dGK, both nucleoside salvage pathway enzymes, are overexpressed in activated T cells.",
  "synonyms": [
    "fluorine F 18 ara-G",
    "[18F]F-ara-G",
    "18F-F-ara-G"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-ara-g/"
}