fluorine F18 BMS-986192

{
  "id": "MLC-T-ONC-013725",
  "term": "fluorine F18 BMS-986192",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer composed of the adnectin BMS-986192, a fibronectin-based protein that targets programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), labeled with the radioisotope fluorine F 18, with potential use for assessing PD-L1 tumor antigen expression using positron emission tomography (PET). Upon administration of fluorine F 18 BMS-986192, the BMS-986192 moiety specifically targets and binds to PD-L1 expressed on certain tumor cells. Upon PET imaging, the radiotracer can be visualized and the extent of PD-L1 expression can be assessed. Adnectins, a protein family derived from the 10th type III domain of human fibronectin with high-affinity targeting capabilities, have favorable physicochemical properties, such as small size, high stability, high affinity and specificity.",
  "synonyms": [
    "18F-BMS-986192",
    "18F-labeled adnectin BMS-986192",
    "18F-labeled anti-PD-L1 adnectin BMS 986192",
    "fluorine F18 BMS 986192",
    "fluorine F18 BMS986192"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f18-bms-986192/"
}