fluorine F 18-WL12

{
  "id": "MLC-T-ONC-013724",
  "term": "fluorine F 18-WL12",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer composed of the programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274)-binding peptide WL12 radiolabeled with the radionuclide fluorine F 18, with potential PD-L1 imaging activity using positron emission tomography (PET). Upon administration of fluorine F 18-WL12, the WL12 moiety targets and binds to PD-L1 expressed on certain tumor cells. Upon uptake and PET imaging, the radioisotope moiety can be visualized and the extent of PD-L1 expression can be assessed. This may be used to predict the therapeutic response to PD-L1-targeting agents.",
  "synonyms": [
    "18F-WL12",
    "fluorine F 18-labeled WL12",
    "[18F]-WL12"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-wl12/"
}