flutamide

{
  "id": "MLC-T-ONC-003276",
  "term": "flutamide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with another drug to treat certain types of prostate cancer. Flutamide binds to proteins called androgen receptors, which are found in some prostate cancer cells. These proteins bind to androgens (male hormones) and may cause cancer cells to grow. Flutamide blocks these proteins and may keep cancer cells from growing. It is a type of antiandrogen.",
    "A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression."
  ],
  "abbreviation": "FLUT",
  "synonyms": [
    "Flucinom",
    "Flugerel",
    "Niftolide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/flutamide/"
}