gallium Ga 68-DOTA-siglec-9

{
  "id": "MLC-T-ONC-013843",
  "term": "gallium Ga 68-DOTA-siglec-9",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical composed of the sialic acid binding Ig-like lectin 9 (siglec-9) linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the positron-emitting radionuclide gallium Ga 68, with potential use in diagnostic imaging upon positron emission tomography (PET). Upon administration of gallium Ga 68-DOTA-siglec-9, the siglec-9 moiety binds to the ligand vascular adhesion protein-1 (VAP-1; amine oxidase, copper containing 3; AOC3) in vasculature. VAP-1 is a homodimeric sialylated glycoprotein with enzymatic activity that is expressed on the endothelium of human tissues such as skin, brain, lung, liver and heart in both normal and inflammatory conditions; it mediates leukocyte migration from the bloodstream to sites of inflammation and can also be found in certain cancers. Siglec-9 is primarily expressed on neutrophils, monocytes, macrophages, and dendritic cells. Detection of siglec-9 binding to VAP-1 using PET may serve as a surrogate marker for inflammation and the presence of cancer cells.",
  "synonyms": [
    "68Ga-DOTA-siglec-9",
    "[68Ga]-DOTA-siglec-9"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-dota-siglec-9/"
}