gallium Ga 68-labeled DOTA Di-HSG peptide IMP-288

{
  "id": "MLC-T-ONC-013853",
  "term": "gallium Ga 68-labeled DOTA Di-HSG peptide IMP-288",
  "field": "Oncology and biomedicine",
  "definition": "A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide gallium (Ga) 68 with potential use in diagnostic imaging. After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against both a tumor-associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of administered gallium Ga 68-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG portion of the BiMoAB; Ga-68 radioisotopic activity localized to tumor cells bearing the TAA can then be visualized upon positron emission tomography (PET).",
  "synonyms": [
    "Ga-68-IMP-288"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-labeled-dota-di-hsg-peptide-imp-288/"
}