guadecitabine

{
  "id": "MLC-T-ONC-003685",
  "term": "guadecitabine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. Guadecitabine may stop the growth of tumor cells by blocking some of the enzymes needed for cells to divide. It may also make cancer cells more sensitive to other anticancer drugs. Guadecitabine is a type of antimetabolite Also called SGI-110.",
    "A dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine."
  ],
  "abbreviation": "DNMT inhibitor SGI-110",
  "synonyms": [
    "SGI-110"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/guadecitabine/"
}