HER2-targeting antibody Fc fragment FS102

{
  "id": "MLC-T-ONC-014108",
  "term": "HER2-targeting antibody Fc fragment FS102",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary, antibody fragment composed of a constant (Fc) region that is engineered to bind to the tumor-associated antigen human epidermal growth factor receptor-2 (HER2), with potential antineoplastic activity. HER2-targeted antibody Fc fragment FS102 specifically binds to its HER2 epitope, and causes downregulation of HER2-mediated signaling. This leads to tumor cell apoptosis. HER2, a member of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) superfamily, is overexpressed on the cell surface of various solid tumors.",
  "synonyms": [
    "anti-HER2 FCAB FS102",
    "Fcab FS102"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/her2-targeting-antibody-fc-fragment-fs102/"
}