horse anti-thymocyte globulin

{
  "id": "MLC-T-ONC-014162",
  "term": "horse anti-thymocyte globulin",
  "field": "Oncology and biomedicine",
  "definition": "A purified, concentrated and sterile solution of horse-derived gamma globulin obtained by the immunization of horses with human T lymphocytes, with T-cell depleting and immunosuppressive activities. Upon administration, horse anti-thymocyte globulin (hATG) specifically recognizes, modulates and destroys T lymphocytes. Although the exact mechanism of action by which hATG causes immunosuppression is not completely understood, it is likely caused by a combination of T-lymphocyte depletion, reduction in T-cell activation and modulation of their cytotoxic activities. Administering of hATG prior to transplantation may reduce the risk of graft-versus-host disease (GvHD).",
  "abbreviation": "hATG",
  "synonyms": [
    "horse ATG",
    "ATG equine",
    "antithymocyte globulin equine",
    "anti-thymocyte globulin equine",
    "equine ATG",
    "lymphocyte immune globulin, anti-thymocyte globulin equine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/horse-anti-thymocyte-globulin/"
}