rabbit anti-thymocyte globulin

{
  "id": "MLC-T-ONC-016334",
  "term": "rabbit anti-thymocyte globulin",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of purified, pasteurized, gamma immune globulin obtained by the immunization of rabbits with human thymocytes, with T-cell depleting and immunosuppressive activities. Upon administration, rabbit anti-thymocyte globulin (rATG) specifically recognizes, modulates and destroys T lymphocytes. Although the exact mechanism of action by which rATG causes immunosuppression is not completely understood, it is likely caused by a combination of T-lymphocyte depletion and reduction in T-cell activation and their cytotoxic activities. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host disease (GvHD).",
  "abbreviation": "rATG",
  "synonyms": [
    "rabbit ATG",
    "rabbit antithymocyte globulin",
    "thymoglobulin",
    "anti-thymocyte globulin rabbit"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rabbit-anti-thymocyte-globulin/"
}