Anti-thymocyte globulin

{
  "id": "MLC-T-ONC-011112",
  "term": "Anti-thymocyte globulin",
  "field": "Oncology and biomedicine",
  "definition": "Purified gamma globulin, with immunosuppressive activity. Obtained from animals that have been immunized with human thymocytes, antithymocyte globulin (ATG) specifically recognizes and destroys T lymphocytes. Although not completely understood, the mechanism of action appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host (GVH) disease.",
  "abbreviation": "ATG",
  "synonyms": [
    "antithymocyte globulin",
    "lymphocyte immune globulin",
    "antithymocyte serum"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-thymocyte-globulin/"
}