Gavilimomab

{
  "id": "MLC-T-ONC-013909",
  "term": "Gavilimomab",
  "field": "Oncology and biomedicine",
  "definition": "A murine IgM monoclonal antibody (MoAb) developed for the potential treatment of graft versus host disease (GvHD). Gavilimomab recognizes human CD147 antigen, weakly expressed on human leukocytes and up-regulated on activated lymphocytes. This MoAb is capable of neutralizing inflammatory reactions via a complement-dependent cytotoxic mechanism. However, gavilimomab does not offer an improvement over antithymocyte globulin in the treatment of acute steroid resistant GVHD.",
  "abbreviation": "MOAB ABX-CBL",
  "synonyms": [
    "ABX-CBL",
    "monoclonal antibody ABX-CBL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gavilimomab/"
}