iodine I 123 ADAM

{
  "id": "MLC-T-ONC-014497",
  "term": "iodine I 123 ADAM",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical containing the serotonin transporter (SERT) ligand ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine] labeled with the radioisotope iodine I 123, with SERT-binding and radioisotope activities. Upon administration, iodine I 123 ADAM selectively binds to SERT-expressing cells; subsequently, SERT-expressing tissues may be visualized using single photon emission computed tomography (SPECT). SERT is a monamine transporter protein found in the membranes of neurons and platelets; in neurons it transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, terminating serotonin's function.",
  "synonyms": [
    "I-123 ADAM",
    "iodine-123-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-123-adam/"
}