Lestaurtinib

{
  "id": "MLC-T-ONC-004788",
  "term": "Lestaurtinib",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug being studied in the treatment of acute leukemias and some other types of cancer. It binds to a protein that is present on the surface of some types of cancer cells and stops them from dividing. Lestaurtinib is a type of receptor tyrosine kinase inhibitor and a type of indolocarbazole alkaloid. Also called CEP-701.",
    "An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3."
  ],
  "synonyms": [
    "CEP-701"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lestaurtinib/"
}