lilotomab

{
  "id": "MLC-T-ONC-014784",
  "term": "lilotomab",
  "field": "Oncology and biomedicine",
  "definition": "A murine immunoglobulin G1 (IgG1) monoclonal antibody directed against the CD37 antigen with potential antineoplastic activity. Upon administration, lilotomab both activates the immune system to induce an antibody-dependent cell-mediated cytotoxicity (ADCC) against CD37-overexpressing tumor cells and induces apoptosis in these tumor cells. CD37 is a transmembrane glycoprotein expressed at high-levels on B-cells and to a lesser extent on T cells and myeloid cells, and is frequently overexpressed in certain B-cell malignancies.",
  "synonyms": [
    "anti-CD37 monoclonal antibody HH1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lilotomab/"
}