Otlertuzumab

{
  "id": "MLC-T-ONC-015720",
  "term": "Otlertuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant single-chain polypeptide engineered to exhibit the full binding and activity of an anti-CD37 monoclonal antibody with potential immunostimulatory and antineoplastic activities. Otlertuzumab binds to CD37 on B-cells, which may result in antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis. CD37 is a transmembrane glycoprotein expressed at high-levels on B cells and to a lesser extent on T cells and myeloid cells. This agent may have a longer half-life in vivo than conventional monoclonal antibodies.",
  "synonyms": [
    "anti-CD37 single-chain polypeptide TRU-016"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/otlertuzumab/"
}