CD20-targeted Polypeptide TRU-015

{
  "id": "MLC-T-ONC-012389",
  "term": "CD20-targeted Polypeptide TRU-015",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary antibody-based single-chain polypeptide with B cell-depleting activity. Significantly smaller than a whole antibody, CD20-targeted polypeptide TRU-015 binds specifically to the B cell-specific cell surface antigen CD20 with full immunoglobulin Fv fragment-type target binding activity and full immunoglobulin Fc fragment-type effector function. This agent transiently depletes CD20-bearing B cells by inducing B-cell-directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) and B-cell apoptosis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd20-targeted-polypeptide-tru-015/"
}