ONYX-015

{
  "id": "MLC-T-ONC-006088",
  "term": "ONYX-015",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged.",
    "An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of ONYX-015-mediated tumor cell cytotoxicity."
  ],
  "expansions": [
    "E1B 55kDa mutant adenovirus dl1520"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/onyx-015/"
}