onzigolide

{
  "id": "MLC-T-ONC-015676",
  "term": "onzigolide",
  "field": "Oncology and biomedicine",
  "definition": "A chimeric dopamine (DA)-somatostatin (SST) compound, with potential antineoplastic activity. Upon administration, onzigolide binds with high affinity to dopamine D2 receptor (D2R) and somatostatin receptor subtype 2 (SSTR2), and to a lesser extent to somatostatin receptor subtype 5 (SSTR5). This agent appears to exert its effect mainly by binding to D2R to activate the ERK1/2 and p38 MAPK pathways, thus inducing apoptosis and inhibiting cellular proliferation in non-functioning pituitary adenoma (NFPA) and neuroendocrine tumors. By binding to SSTR2, this agent may inhibit the secretion of growth hormone (GH) by the pituitary gland.",
  "synonyms": [
    "dopamine-somatostatin chimeric molecule TBR-760"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/onzigolide/"
}