anti-SSTR2/CD3 monoclonal antibody XmAb18087

{
  "id": "MLC-T-ONC-011099",
  "term": "anti-SSTR2/CD3 monoclonal antibody XmAb18087",
  "field": "Oncology and biomedicine",
  "definition": "A humanized, Fc domain-containing, bispecific monoclonal antibody targeting human CD3, a T-cell surface antigen, and somatostatin receptor 2 (SSTR2), a tumor-associated antigen (TAA) expressed on certain cancer cells, with potential antineoplastic activity. Upon administration, anti-SSTR2/CD3 monoclonal antibody XmAb18087 binds to both T cells and SSTR2-expressing cancer cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the SSTR2-expressing cancer cells. The inclusion of an Fc domain on the antibody prolongs the half-life of the bispecific antibody.",
  "synonyms": [
    "anti-SSTR2 x anti-CD3 monoclonal antibody XmAb18087"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-sstr2-cd3-monoclonal-antibody-xmab18087/"
}