lipopolysaccharide

{
  "id": "MLC-T-ONC-014810",
  "term": "lipopolysaccharide",
  "field": "Oncology and biomedicine",
  "definition": "An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens.",
  "abbreviation": "LPS",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lipopolysaccharide/"
}