Monophosphoryl lipid A

{
  "id": "MLC-T-ONC-015276",
  "term": "Monophosphoryl lipid A",
  "field": "Oncology and biomedicine",
  "definition": "A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TLR4) agonist, with potential immunostimulatory activity. As a vaccine adjuvant, monophosphoryl lipid A (MPLA) stimulates both cellular and humoral responses to the vaccine antigen. Compared to LPS, MPLA exerts a similar immunostimulatory activity but with reduced toxicity.",
  "abbreviation": "MPL",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/monophosphoryl-lipid-a/"
}