TLR-directed cationic lipid-DNA complex JVRS-100

{
  "id": "MLC-T-ONC-017214",
  "term": "TLR-directed cationic lipid-DNA complex JVRS-100",
  "field": "Oncology and biomedicine",
  "definition": "A cationic lipid DNA complex (CLDC) consisting of DOTIM/cholesterol liposomes and plasmid DNA, containing immunostimulatory CpG and non-CpG motifs, with potential immunostimulating and antineoplastic activities. Upon systemic administration, TLR-directed cationic lipid-DNA complex JVRS-100 enters dendritic cells (DCs) and macrophages; immunostimulatory DNA binds to and activates Toll-like receptors (TLRs), which may result in the generation of anti-tumor natural killer (NK) cell and T-cell responses by the innate immune system. In addition, as a vaccine adjuvant, this agent may induce a strong cytotoxic T-lymphocyte (CTL) response to co-administered antigen.",
  "synonyms": [
    "Toll-like receptor-directed cationic lipid-DNA complex JVRS-10"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr-directed-cationic-lipid-dna-complex-jvrs-100/"
}