TLR9 agonist DUK-CPG-001

{
  "id": "MLC-T-ONC-017209",
  "term": "TLR9 agonist DUK-CPG-001",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic CpG-rich oligonucleotide with potential immunopotentiating activity. TLR9 agonist DUK-CPG-001 binds to and activates intracellular toll-like receptor 9 (TLR9) in monocytes/macrophages, plasmacytoid dendritic cells (DCs), natural killer (NK) cells and B cells. This initiates immune signaling pathways, activates DCs, NK cells and B cells, and induces both the production of T-helper 1 cells (Th1) and a Th1-mediated immune response. TLR9 is a member of the TLR family, which plays a key role in both pathogen recognition and the activation of innate immunity.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr9-agonist-duk-cpg-001/"
}