CpG oligodeoxynucleotide TLR9 agonist DV281

{
  "id": "MLC-T-ONC-012791",
  "term": "CpG oligodeoxynucleotide TLR9 agonist DV281",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary synthetic, aerosolized C-class CpG oligodeoxynucleotide-based (ODN) agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon inhalation, CpG ODN TLR9 agonist DV281 specifically targets, binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against antigens expressed by lung cancer cells. TLR9, a member of the TLR family, plays a fundamental role in pathogen recognition and activation of the innate immune system.",
  "synonyms": [
    "CpG ODN TLR9 agonist DV281",
    "TLR9 agonist DV281"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cpg-oligodeoxynucleotide-tlr9-agonist-dv281/"
}