tilsotolimod sodium

{
  "id": "MLC-T-ONC-017169",
  "term": "tilsotolimod sodium",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary synthetic oligonucleotide-based agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon administration, tilsotolimod sodium binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B cells. This initiates immune signaling pathways, activates B cells and pDCs, and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.",
  "synonyms": [
    "TLR9 agonist IMO-2125"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tilsotolimod-sodium/"
}