TLR agonist Decoy20

{
  "id": "MLC-T-ONC-017194",
  "term": "TLR agonist Decoy20",
  "field": "Oncology and biomedicine",
  "definition": "A multi-targeted toll-like receptor (TLR) agonist, with potential immunomodulating and antineoplastic activities. Upon administration, TLR agonist Decoy20 activates one or more not yet disclosed TLRs expressed on various immune cells, such as macrophages and plasmacytoid dendritic cells (pDCs), which results in their stimulation, the production of certain pro-inflammatory cytokines, and the upregulation of co-stimulatory molecules. This may lead to enhanced T- and B-cell stimulatory responses, cytotoxic T-cell proliferation, a T-helper 1 (Th1) immune response, and immune-mediated tumor cell killing. TLRs are transmembrane receptors that recognize structurally conserved microbial molecules such as bacterial cell-surface lipopolysaccharides (LPS), lipoproteins, lipopeptides, lipoarabinomannan and flagellin, among others. Immune responses stimulated by TLR activation may result in innate and adaptive immune-mediated tumor cell killing.",
  "synonyms": [
    "Toll-like receptor agonist Decoy20"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr-agonist-decoy20/"
}