TLR1/2 agonist Pam3Cys-GDPKHPKSF

{
  "id": "MLC-T-ONC-017195",
  "term": "TLR1/2 agonist Pam3Cys-GDPKHPKSF",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine adjuvant and synthetic Toll-like receptor (TLR) type 1 and 2 ligand composed of a lipopeptide containing a water-soluble derivative of Pam3-Cys, the biologically active component of the mycobacterial 19 kDa lipoprotein of mycobacteria, that is covalently linked to a synthetic peptide (GDPKHPKSF), with potential immunostimulating activity. Upon administration, TLR1/2 agonist Pam3Cys-GDPKHPKSF targets, binds to and activates TLR1/2, which induces CD8- and T-helper 1 CD4-positive T-cell responses. This may enhance T-cell-mediated immune responses when administered together with peptide vaccine.",
  "synonyms": [
    "TLR1/2 agonist XS15",
    "TLR1/2 ligand XS15",
    "Pam3Cys-GDPKHPKSF XS15"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr1-2-agonist-pam3cys-gdpkhpksf/"
}