TLR4 agonist GSK1795091

{
  "id": "MLC-T-ONC-017197",
  "term": "TLR4 agonist GSK1795091",
  "field": "Oncology and biomedicine",
  "definition": "A toll-like receptor 4 (TLR4) agonist, with potential immunoadjuvant activity. Upon administration, GSK1795091 binds to and activates TLR4, thereby stimulating dendritic cells (DCs), monocytes and macrophages. This activation results in the production of pro-inflammatory cytokines, including interferon gamma (IFN-g), tumor necrosis factor-alpha (TNF-a) and the interleukins (IL), IL-1 beta, -6 and -12. This may induce a T helper cell-1 (Th1) immune response and, upon co-administration of a vaccine containing tumor-associated antigens (TAAs), activates a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing those TAAs. TLR4, a member of the TLR family, plays a key role in the activation of innate immunity.",
  "synonyms": [
    "Toll-like receptor 4 agonist GSK1795091",
    "TLR 4 agonist GSK1795091"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tlr4-agonist-gsk1795091/"
}