MLchartDataset catalogue

LOH

Term · Oncology and biomedicine · MLC-T-ONC-004918

If there is one normal and one abnormal allele at a particular locus, as might be seen in an inherited autosomal dominant cancer susceptibility disorder, loss of the normal allele produces a locus with no normal function. When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor suppressor gene. Also called loss of heterozygosity.

Table 1. Record
IdentifierMLC-T-ONC-004918
FieldOncology and biomedicine
Expansionsloss of heterozygosity
ReferencesNCI Dictionary of Genetics Terms
Record as JSON 
{
  "id": "MLC-T-ONC-004918",
  "term": "LOH",
  "field": "Oncology and biomedicine",
  "definition": "If there is one normal and one abnormal allele at a particular locus, as might be seen in an inherited autosomal dominant cancer susceptibility disorder, loss of the normal allele produces a locus with no normal function. When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor suppressor gene. Also called loss of heterozygosity.",
  "expansions": [
    "loss of heterozygosity"
  ],
  "references": [
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/loh/"
}

Record 10,282 of 17,717 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.