loss of heterozygosity

{
  "id": "MLC-T-ONC-004938",
  "term": "loss of heterozygosity",
  "field": "Oncology and biomedicine",
  "definition": "If there is one normal and one abnormal allele at a particular locus, as might be seen in an inherited autosomal dominant cancer susceptibility disorder, loss of the normal allele produces a locus with no normal function. When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor suppressor gene. Also called LOH.",
  "synonyms": [
    "LOH"
  ],
  "references": [
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/loss-of-heterozygosity/"
}