lometrexol

{
  "id": "MLC-T-ONC-004919",
  "term": "lometrexol",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antifolates.",
    "A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate."
  ],
  "abbreviation": "LMTX",
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lometrexol/"
}