lurbinectedin

{
  "id": "MLC-T-ONC-004985",
  "term": "lurbinectedin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with small cell lung cancer that has spread to other parts of the body and got worse during or after treatment with platinum chemotherapy. It is also being studied in the treatment of other types of cancer. Lurbinectedin may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent. Also called Zepzelca.",
    "A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death."
  ],
  "synonyms": [
    "Zepzelca"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lurbinectedin/"
}