Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115

{
  "id": "MLC-T-ONC-015086",
  "term": "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of tumor-infiltrating lymphocytes (TILs) that have been genetically engineered to express membrane-bound IL-15 (mbIL15), with potential immunostimulating and antineoplastic activities. Upon introduction of the mbIL15-expressing TILs OBX-115, the TILs target and kill tumor cells. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells. Sustained IL-15 signaling enhances TIL persistence and potency compared to un-engineered TILs. OBX-115 may replace the need for concomitant administration of systemic IL-2 which is needed to improve the efficacy of conventional TILs.",
  "synonyms": [
    "IL15-engineered TILs OBX-115",
    "bIL15-expressing TILs OBX-115",
    "CytoTIL15",
    "IL-15-engineered TILs OBX-115",
    "IL-15-engineered tumor-infiltrating lymphocytes OBX-115"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/membrane-bound-il-15-expressing-tumor-infiltrating-lymphocytes-obx-115/"
}